Rapid development of NLS-technologies (Biophilia Intruder)
Rapid development of NLS-technologies (Biophilia Intruder)
Diagnosis and staging of new malignancies.
Over the past few years, there has been some evidence of rapid development of NLS techniques targeting various localized diagnostics and new growth staging procedures. The multi-layer spiral computer NLS-scopy is a breakthrough for clinical use of all hardware technologies. Two main advantages of this technique can be achieved using the NLS-scopy method: increased scanning speed and spatial resolution. The increase in scan speed is proportional to the number of parallel processors used. Compared to the previous generation Biophilia Intruder's NLS system, the use of the LAPP system (4 parallel supercomputing power and performance processor systems) can reduce the scan interval for a given anatomical region by a factor of 8. In practice, for example, this means a 3-5 second abdominal or breast exam. The increased speed allows the simultaneous examination of several anatomical areas: breast, abdomen, head, neck and upper part of the breast, which has important implications in oncology practice. Examination of the extremities is possible, including long bone, single or double spine slices available only prior to the use of MRT.
A second advantage of NLS diagnosis is the reduced scan area due to the maximum possible increase in spatial resolution. Ultrastructural dimensions down to 100-200 microns can be studied when using the Oberon system, while 5-10 microns can be examined using the Biophilia Intruder system. This technique offers an option to expose pathological growths of this size. In clinical practice, they usually choose from the maximum possible study speed and maximum possible resolution under given conditions.
The increase in resolution has another important significance. When the layer thickness is 5-10 microns, so-called isotropic images are formed. In this case, the image matrix consists of voxels with equal or nearly equal edges (having the shape of a cube). The resolution along the axial and longitudinal planes is equal, allowing the actual 2D and 3D transformation of the inspection area to be established at the end of the inspection.
The use of NLS in clinical practice has significantly increased angiographic studies based on scans of selected anatomical regions as a bolus of angiographic contrast agent passes through. Combined with various virtual transformation methods, it can study the vascular lumen, thrombus exposure; supervise the relationship between blood vessels and pathological tumors. Virtual NLS endoscopy is widely used in oncology practice, especially colonoscopy, angioscopy, bronchoscopy, sinus endoscopy, etc.
The rapid development of the NLS is characterized by a completely new software for the system (the Biophilia Intruder program). The main trend here is less time to gather information to conduct adequate research. Another NLS development line is the Z-Series scanner, with which multiple anatomical regions can be examined during a single study lasting 10-15 minutes. In this context, the most demonstrative are whole-organism NLS studies targeting primary tumor searches or the effects of a single metastatic organ or tissue.
The importance of NLS continues to increase due to equipment upgrades and monitoring of functional status and standard medications for various organs and systems. Currently, oncology and cardiology are among the main complementary positions for this technology. Numerous studies, such as those with prospective and retrospective approaches, suggest that NLS appears to be one of the most effective methods for uncovering malignant tissue. If the sensitivity and specificity indicators CP and MRT account for 60-90% of tumor exposure in different localizations, then similar NLS indicators in all studies are almost over 80%. Meanwhile, the smallest pathological tumor size shown by NLS was 0,3-0,5 mm. NLS has fundamental value in the differential diagnosis of cancerous and noncancerous growths, primary tumor exposure in the context of metastatic influence in various organs and tissues, and determination of the prevalence of primary tumors when regional glandular and distant organ metastasis is unknown. In all of the above clinical cases, the self-descriptive nature of NLS surpasses all morphological visualizations of traditional techniques.
The main disadvantage of NLS is that, as with most hardware methods, it is difficult to make a precise local diagnosis of exposed pathological growths and to determine the relationship between the tumor and its surrounding tissues and organs. For this, they now use CT. The advent of the combined use of NLS/CT has become natural, allowing two studies to be performed almost simultaneously, with simultaneous anatomical CT and virtual NLS image color registration. The expediency of this concept in diagnosis is widely debated