Preliminary Diagnosis of Celiac Disease with Biophilia Tracker X3

Preliminary Diagnosis of Celiac Disease with Biophilia Tracker X3

Intrahepatic cholangiocarcinoma is diagnosed in 7-35% of all malignant liver tumor cases. Early detection of this pathology is one of the most difficult tasks in hepatological diagnosis, since tumors often develop in the context of chronic diseases of the liver and bile excretory ducts and are masked by the symptoms of these diseases.

There has been a cyclical increase in the detection of cholangiocarcinoma in recent years. It is explained by the introduction of modern visualization methods, which allow a more accurate specification of the localization and prevalence of tumor processes. The peak incidence is 50-70 years old. The disease occurs almost equally in men and women.

The main accompanying syndromes of the disease are obstructive jaundice and cholestasis, which greatly reduces the regenerative capacity of the parenchyma. Suppurative cholangitis develops later in the disease and is sometimes the cause of death in patients.

Cholangiocarcinoma has an adenoid structure, originates from the intrahepatic bile duct epithelium, and contains keratin, which explains its density. Tumors may develop at any level of the biliary tree and spread to the liver. Since the tumor is characterized by a slow infiltrating growth within or along the vessel wall, it does not form a clearly visible volume tumor and has no well-defined borders. When the tumor squeezes the bile duct, biliary hypertension of varying intensity and dilation of the overlying portion of the bile duct (depending on tumor spread) occur. Below the point of obstruction, total bile powder diameter and gallbladder size decrease.

Analysis of clinical symptoms and biochemical markers alone does not always reveal the cause of cholestasis, especially in patients with relatively short and low hyperbilirubinemia. Equally important, the majority of patients with the disease are elderly and have been taken to the hospital's surgical department with complications.

The only effective treatment for cholangiocarcinoma is surgical intervention, which underscores the importance of prompt testing to detect "smaller" tumors. The 5-year survival rate for patients with small tumors is 85%. The main factor that determines tumor resectability is the functional likelihood of the remainder of the liver.

The most important methods for the initial diagnosis of bile excretion dust pathology are non-invasive research methods (ultrasound scanning, computed tomography, and magnetic resonance imaging). But these methods cannot clearly detect the localization of the focal process and its characteristics. Based on the data obtained, the therapist decides on more accurate invasive diagnostic methods: endoscopic retrograde cholangiopancreatography (ERCPG), percutaneous transhepatic cholangiopancreatography (PTCG), and in some cases - angiographic studies and liver biopsy. The choice of method depends on its availability, information value, security and affordability.

The recently emerging nonlinear diagnostic (NLS) approach may now be the most available method for the initial diagnosis of celiac disease. One of the most promising trends in NLS diagnosis proposed by the Biophilia Tracker X3 is 3D NLS imaging, which has certain technical and practical advantages in the visualization of anatomical and pathological structures compared to other hardware visualization methods. The computer-processed data can be processed and the 3D model transverse planes can be adjusted so that organ images in various projections can be studied.