Biophilia Tracker could become a primary method for peripheral nerve tumor diagnosis

NLS studies using the Biophilia Tracker could become a primary method for peripheral nerve tumor diagnosis

Neurofibromas (fibroneuromas) are benign tumors of peripheral nerves that develop from Schwann cells and fibroblasts, usually on the surface, deep, or subcutaneous layer of the subcutaneous tissue. It is extremely rare for a single neurofibroma to function as an independent disease unit. The more common presence of neurofibromas is a sign of a genetic disorder - neurofibromas.

Neurofibromatosis type II (NF2) was first described by Scottish surgeon Wishart J.H. in 1822. In 1882, von Recklinghausen F.D. studied and described neurofibromas type 1 (NF1). Although the descriptions of the diseases differed, Cushing H.W. in 1916 unified them under a single name "Recklinghausen disease" in scientific work. Fundamental differences in the pathogenesis of NF1 and NF2 were not revealed until years later, through molecular genetic testing (the results of which were published in 1985 and 1987, respectively). As it turns out, these are completely different diseases that require different diagnostics and medical strategies.

Eight types of NF are described in scientific references, but with the exception of NF2, most are considered abortive forms of NF1 and are not considered separate forms of disease classification. The exception is segmental NF (NF type 5) (NF5), where the typical manifestation of NF1 is located in one or more adjacent dermatomes (rarely occurs, usually not inherited) and is not included in all spine 8 NF middle. The ridge root is affected symmetrically (several observations are described).

Neurosurgeons and surgeon-orthopaedic surgeons base their diagnosis primarily on the clinical manifestations of pathology, recall data, and patient examination findings, but are insufficient to reveal space-occupying soft-tissue tumors of peripheral nerves. In order to determine tumor location during planned surgical treatment, additional tool research methods are required. Diagnosis of this pathology using electromyography often does not give accurate results because patients usually do not have nerve trunk conductance abnormalities or, if the tumor is located next to a major nerve trunk, only mild or moderate conductance abnormalities are found. Radiographic diagnosis The application of methods in peripheral nerve tumors is often limited by the technical possibilities of the study. In the case of nerve trunks or soft tissue, tumor radiography has no diagnostic significance and can only be used to eliminate skeletal lesions.

Computed tomography as well as radiography do not provide the required amount of information in this pathology. Magnetic resonance imaging (MRI) is a method of choice for the diagnosis of soft-tissue mass-occupying tumors, including those associated with large nerve trunks and plexuses. However, interpretation of received results can be complicated if the mass-occupying tumor is small and has an oblique angle to the tomographic section. Therefore, NLS-research using biophilic trackers has recently emerged, which, in our opinion, could become the primary method for screening and diagnosis of peripheral nerve tumors.

Biophilia Tracker's stronger features, larger database, are bringing better help.

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