Biophilia Tracker combined with NLS and MRI for soft tissue sarcoma

Biophilia Tracker combined with NLS and MRI for soft tissue sarcoma

Following the widespread introduction of NLS and MRI into clinical practice, the role and place of hardware approaches in soft tissue tumor research has become even more important. At the same time, these soft tissue tumor research methods face the following goals: 1) tumor detection; 2) tumor identification (differential diagnosis); 3) disease stage identification. The 3D NLS examination performed by the Biophilia Tracker together with REA allowed us to detect the presence of tumors, their size and structure with high precision. MRI and NLS are nearly equally informative in assessing local spread in soft tissue sarcoma. The strength of the NLS study is the ability to differentiate between solid and cystic tumors when used with REA, which is especially important in the case of myxomas or mixed tumor-like tumors, which may be erroneously interpreted as cysts due to their high water content. CT or MRI. In addition, NLS studies can identify tumor areas most suitable for needle biopsy (to differentiate between hyperpigmented solid areas and necrosis). Another advantage of NLS studies is monitoring patients after surgical intervention and after chemotherapy.

MRI is recognized as the most effective method for the diagnosis of soft tissue injuries because it achieves all three of the above goals of soft tissue research with high precision. Comprehensive assessment of the most important MRI criteria for tumor examination (size, contour, homogeneity, signal intensity) allowed us to predict malignancy in 82% – 96% of cases. Combined with the high sensitivity of MRI in the study of soft tissue tumors, its specificity is low. An approximate histological diagnosis can be found in 25% – 50% of cases (in 65% – 80% of cases when we apply NLS studies with REA).

When interpreting MRI images, the most important metric is the MR signal intensity from the tumor. In the case of various soft-tissue tumors, we can see typical MR signal-altered renal foci and foci on MRI images, based on their intensity and homogeneity (or heterogeneity) as well as tumor localization, form, The structure and contours and condition of the surrounding tissue, we can decide whether the pathological features are malignant or benign, its staging, and in some cases - roughly determine the histological attribution of the tumor.

One of the main criteria for the differential diagnosis of tumors is to assess the tumor blood supply. MRI is a highly informative method for detecting tumor vascularization, neovascularization characteristics and types.

In most cases, studies of vascularization of soft tissue tumors have found that neovascularization is mainly located in the peripheral region of the tumor or so-called compound vascularization (vascularization in both the peripheral region and the center of the tumor).

Neovascularization differs from normal vessels by the non-uniform diameter, sinus-like structure, branches, and the presence of numerous arteriovenous shunts.

The data obtained therefore lead us to conclude that MRI and NLS studies are of high informative value in examining patients with soft tissue tumors. However, MRI data are very characteristic for such tumors and show their morphogenesis while the NLS study is an effective diagnostic screening method. The application of combined NLS, MRI and MRA examinations can address many specific problems in the diagnosis of soft tissue tumors: identification of tumor location, form, size, structure, volume and local spread, assessment of signs of malignancy, vascularization of tumors and their relationship to large vessels and bone structure, which are the main criteria for selecting treatment strategies.