Biophilia Intruder has been used to treat more skin diseases
Biophilia Intruder has been used to treat more skin diseases
The Biophilia Intruder has an axial resolution of 30 µm. The application of this device allows the study of the epidermis at the cellular and subcellular levels.
Today, the research goals and limitations of 3D NLS ultra-microscopic scanning in dermatology have become very broad.
The following has become a reality:
- To evaluate the effects of treatment in diseases characterized by skin sclerosis (localized scleroderma, systemic scleroderma), edema (fatty skin sclerosis) and chronic inflammatory (psoriatic) skin diseases;
- Measurement of skin tumor invasion and monitoring of surgical intervention, monitoring of cryotherapy and laser therapy for melanoma, basaloid carcinoma, hemangiomas, fibroids, seborrheic keratosis;
- To study the effects of topical and systemic drugs on the skin (corticosteroids, estradiol).
According to the methods, NLS ultra-scanning diagnosis of skin diseases must be made by comparing the affected area with healthy skin of the contralateral homologous area.
In NLS imaging using a non-linear sensor at a frequency of 4.9 GHz, normal skin is represented by three layers: epidermis, dermis, and subcutaneous tissue. The regional and age-related properties of skin thickness depend primarily on the thickness of the dermis, which is primarily dependent on the collagen content therein.
It is believed that visualization of normal epidermis is poor in NLS studies with a sensor frequency of 1.4 GHz because the actual thickness of epidermis is 0.02 – 0.5 mm, which is a resolution limit for such systems.
The epidermis is a moderately pigmented structure (2-3 on the Fleindler scale), and its pigmentation depends on the thickness of the stratum corneum and the rate of desquamation.
UHF nonlinear sensors can study more of the superficial papillary layer of the dermis and the underlying reticular layer, which is characterized by a more homogeneous structure.
For the differential diagnosis of skin tumors such as hemangioma or melanoma, the modalities of ultra-microscopic scanning and spectral entropy analysis (SEA) can be successfully applied.